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Target
Arginase-1
Ligand
BDBM50511671
Substrate
n/a
Meas. Tech.
ChEMBL_1845384 (CHEMBL4345811)
IC50
78±n/a nM
Citation
 Blaszczyk, R; Brzezinska, J; Dymek, B; Stanczak, PS; Mazurkiewicz, M; Olczak, J; Nowicka, J; Dzwonek, K; Zagozdzon, A; Golab, J; Golebiowski, A Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors. ACS Med Chem Lett 11:433-438 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50511671
Synonyms:
CHEMBL4566202
Type:
Small organic molecule
Emp. Form.:
C9H21BN4O4
Mol. Mass.:
260.098
SMILES:
CNC(CCCCB(O)O)(CNC(N)=N)C(O)=O
Structure:
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