Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50066515
Substrate
n/a
Meas. Tech.
ChEMBL_66901 (CHEMBL675383)
IC50
2300±n/a nM
Citation
 Furet, P; Gay, B; Caravatti, G; García-Echeverría, C; Rahuel, J; Schoepfer, J; Fretz, H Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain. J Med Chem 41:3442-9 (1998) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50066515
Synonyms:
2-(2-{2-Amino-3-[4-(diacetoxy-phosphoryloxy)-phenyl]-propionylamino}-hexanoylamino)-N-(3-phenyl-propyl)-succinamic acid | CHEMBL324094
Type:
Small organic molecule
Emp. Form.:
C32H43N4O11P
Mol. Mass.:
690.6778
SMILES:
CCCCC(NC(=O)C(N)Cc1ccc(OP(=O)(OC(C)=O)OC(C)=O)cc1)C(=O)NC(CC(=O)NCCCc1ccccc1)C(O)=O
Structure:
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