Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50067014
Substrate
n/a
Meas. Tech.
ChEMBL_200984 (CHEMBL873113)
IC50
41±n/a nM
Citation
 Berardi, F; Santoro, S; Perrone, R; Tortorella, V; Govoni, S; Lucchi, L N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands. J Med Chem 41:3940-7 (1998) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50067014
Synonyms:
5-[3-(3,3-Dimethyl-piperidin-1-yl)-propyl]-5,6,7,8-tetrahydro-naphthalen-1-ol | CHEMBL338465
Type:
Small organic molecule
Emp. Form.:
C20H31NO
Mol. Mass.:
301.4662
SMILES:
CC1(C)CCCN(CCCC2CCCc3c(O)cccc23)C1
Structure:
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