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Target
Sterol O-acyltransferase 1
Ligand
BDBM50242257
Substrate
n/a
Meas. Tech.
ChEMBL_1849337 (CHEMBL4349878)
IC50
12000±n/a nM
Citation
 Ohshiro, T; Kobayashi, K; Suzuki, A; Yamazaki, H; Uchida, R; Namikoshi, M; Tomoda, H Inhibition of neutral lipid synthesis by avarols from a marine sponge. Bioorg Med Chem Lett 29:2283-2285 (2019) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT | ACAT-1 | ACAT1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1 | SOAT1_CRIGR
Type:
PROTEIN
Mol. Mass.:
64129.93
Organism:
Cricetulus griseus
Description:
ChEMBL_102587
Residue:
546
Sequence:
MVGEEKMSLRNRLSKSGENPEQDEAQRSVSDTQSNGRITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEKGKIFISRRSLLDELFEVDHIRTIYHMFIGLLILFILSTLVVDYIDEGRLVLEFNLLGYAFGKLPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKTSHPLIYSLSHGFFFLVFQLGILGFVPTYVVLAYTLPPASRFIVILEQIRMVMKAHSFVRENVPRVLNAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAVQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGHGVILCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCQYVF
  
Inhibitor
Name:
BDBM50242257
Synonyms:
2-((1R,2S,4aS)-1,2,4a,5-Tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol | 2-(1,2,4a,5-Tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol(Avarol)(Avarol) | Avarol | Avrol | CHEMBL459814
Type:
Small organic molecule
Emp. Form.:
C21H30O2
Mol. Mass.:
314.4617
SMILES:
C[C@H]1CC[C@@]2(C)[C@@H](CCC=C2C)[C@]1(C)Cc1cc(O)ccc1O |r,c:9|
Structure:
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