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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50067759
Substrate
n/a
Meas. Tech.
ChEMBL_28169 (CHEMBL644123)
IC50
45±n/a nM
Citation
 Tanaka, A; Terasawa, T; Hagihara, H; Ishibe, N; Sawada, M; Sakuma, Y; Hashimoto, M; Takasugi, H; Tanaka, H Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem 41:4408-20 (1998) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50067759
Synonyms:
3-(2,4-Bis-methanesulfonyl-6-methyl-pyridin-3-yl)-1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-urea | CHEMBL138323
Type:
Small organic molecule
Emp. Form.:
C29H34FN3O6S2
Mol. Mass.:
603.725
SMILES:
Cc1cc(c(NC(=O)N(Cc2ccc(Oc3ccc(F)cc3)cc2)C2CCCCCC2)c(n1)S(C)(=O)=O)S(C)(=O)=O
Structure:
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