Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM209265
Substrate
n/a
Meas. Tech.
ChEMBL_1850434 (CHEMBL4351058)
IC50
18±n/a nM
Citation
 Gehringer, M; Laufer, SA Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology. J Med Chem 62:5673-5724 (2019) [PubMed]  Article 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen=CD334 | FGFR4_MOUSE | Fgfr-4 | Fgfr4 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 | Mpk-11 | Protein-tyrosine kinase receptor MPK-11
Type:
PROTEIN
Mol. Mass.:
88660.29
Organism:
Mus musculus
Description:
ChEMBL_820929
Residue:
799
Sequence:
MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLEPSPFPFSDSQTT
  
Inhibitor
Name:
BDBM209265
Synonyms:
US9266883, 23
Type:
Small organic molecule
Emp. Form.:
C19H19N5O4
Mol. Mass.:
381.3853
SMILES:
COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N
Structure:
Search PDB for entries with ligand similarity: