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Target
Cysteine proteinase falcipain 3
Ligand
BDBM50513166
Substrate
n/a
Meas. Tech.
ChEMBL_1852105 (CHEMBL4352729)
IC50
480±n/a nM
Citation
 Stoye, A; Juillard, A; Tang, AH; Legac, J; Gut, J; White, KL; Charman, SA; Rosenthal, PJ; Grau, GER; Hunt, NH; Payne, RJ Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem 62:5562-5578 (2019) [PubMed]  Article 
Target
Name:
Cysteine proteinase falcipain 3
Synonyms:
Cysteine protease falcipain-3
Type:
Protein
Mol. Mass.:
56666.98
Organism:
Plasmodium falciparum
Description:
Q9NAW4
Residue:
492
Sequence:
MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
  
Inhibitor
Name:
BDBM50513166
Synonyms:
CHEMBL4527228
Type:
Small organic molecule
Emp. Form.:
C43H59F3N6O8
Mol. Mass.:
844.9592
SMILES:
OC(=O)C(F)(F)F.COC1=CC(=O)N([C@H]1Cc1c[nH]c2ccccc12)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)C1CCN(C)CC1 |r,t:8|
Structure:
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