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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50513209
Substrate
n/a
Meas. Tech.
ChEMBL_1852374 (CHEMBL4352998)
Ki
0.880000±n/a nM
Citation
 Liu, Y; Wang, X; Wang, G; Yang, Y; Yuan, Y; Ouyang, L The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. Eur J Med Chem 176:92-104 (2019) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50513209
Synonyms:
CHEMBL4440151
Type:
Small organic molecule
Emp. Form.:
C29H34Cl2FN3O3
Mol. Mass.:
562.503
SMILES:
CC(C)(C)C[C@H]1NC([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:17.29,8.8,31.34,wD:5.4,34.38,(26.42,-21.67,;26.71,-23.19,;27.79,-22.08,;28.16,-23.69,;25.54,-24.19,;24.09,-23.68,;23.64,-22.2,;22.09,-22.17,;21.58,-23.63,;20.07,-23.32,;19.59,-21.85,;18.08,-21.55,;17.05,-22.71,;17.55,-24.18,;16.53,-25.33,;19.06,-24.48,;18.28,-25.8,;22.81,-24.57,;24.07,-25.48,;25.53,-25,;23.58,-26.94,;22.04,-26.94,;21.02,-28.08,;19.52,-27.77,;18.49,-28.92,;19.04,-26.31,;20.07,-25.16,;21.57,-25.48,;21.65,-20.69,;20.15,-20.33,;22.71,-19.57,;22.28,-18.1,;20.79,-17.74,;20.37,-16.26,;21.43,-15.16,;21,-13.68,;22.92,-15.53,;23.35,-16.99,)|
Structure:
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