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Target
Glucagon receptor
Ligand
BDBM32012
Substrate
n/a
Meas. Tech.
ChEMBL_72990 (CHEMBL680803)
Ki
55000±n/a nM
Citation
 Madsen, P; Knudsen, LB; Wiberg, FC; Carr, RD Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists. J Med Chem 41:5150-7 (1999) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM32012
Synonyms:
1-(3,4-Dihydroxy-phenyl)-2-(5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethanone | 1-(3,4-dihydroxyphenyl)-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone | 1-(3,4-dihydroxyphenyl)-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]ethanone | 1-[3,4-bis(oxidanyl)phenyl]-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone | CHEMBL358546 | MLS000074715 | SMR000011758 | cid_654283
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3S
Mol. Mass.:
327.358
SMILES:
Oc1ccc(cc1O)C(=O)CSc1nnc([nH]1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: