Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 3
Ligand
BDBM50030476
Substrate
n/a
Meas. Tech.
ChEMBL_1853466 (CHEMBL4354090)
EC50
570±n/a nM
Citation
 Liang, D; Li, L; Lynch, C; Mackowiak, B; Hedrich, WD; Ai, Y; Yin, Y; Heyward, S; Xia, M; Wang, H; Xue, F Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies. Eur J Med Chem 179:84-99 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 3
Synonyms:
CAR | NR1I3 | NR1I3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39953.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1434936
Residue:
352
Sequence:
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
  
Inhibitor
Name:
BDBM50030476
Synonyms:
CHEMBL458603
Type:
Small organic molecule
Emp. Form.:
C19H12Cl3N3OS
Mol. Mass.:
436.742
SMILES:
Clc1ccc(cc1)-c1nc2sccn2c1\C=N\OCc1ccc(Cl)c(Cl)c1
Structure:
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