Reaction Details Report a problem with these data
Target
Kallikrein-14
Ligand
BDBM50513783
Substrate
n/a
Meas. Tech.
ChEMBL_1854456 (CHEMBL4355185)
Ki
79±n/a nM
Citation
 Li, CY; de Veer, SJ; White, AM; Chen, X; Harris, JM; Swedberg, JE; Craik, DJ Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. J Med Chem 62:3696-3706 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-14
Synonyms:
KLK-L6 | KLK14 | KLK14_HUMAN | KLKL6 | Kallikrein 14 | Kallikrein-14 | Kallikrein-like protein 6 | hK14
Type:
PROTEIN
Mol. Mass.:
29136.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282452
Residue:
267
Sequence:
MSLRVLGSGTWPSAPKMFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK
  
Inhibitor
Name:
BDBM50513783
Synonyms:
CHEMBL4456620
Type:
Small organic molecule
Emp. Form.:
C74H96N20O19S2
Mol. Mass.:
1633.807
SMILES:
NC(=O)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N2 |r|
Structure:
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