Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50514105
Substrate
n/a
Meas. Tech.
ChEMBL_1855652 (CHEMBL4356381)
EC50
3.2±n/a nM
Citation
 Wágner, G; Mocking, TAM; Arimont, M; Provensi, G; Rani, B; Silva-Marques, B; Latacz, G; Da Costa Pereira, D; Karatzidou, C; Vischer, HF; Wijtmans, M; Kie?-Kononowicz, K; de Esch, IJP; Leurs, R 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H J Med Chem 62:10848-10866 (2019) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50514105
Synonyms:
CHEMBL4441731
Type:
Small organic molecule
Emp. Form.:
C14H23N5O5
Mol. Mass.:
341.3629
SMILES:
O.OC(=O)\C=C\C(O)=O.CCCNC1CN(C1)c1ccnc(N)n1
Structure:
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