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Target
Endothelin receptor type B
Ligand
BDBM50069564
Substrate
n/a
Meas. Tech.
ChEBML_63869
IC50
>10000±n/a nM
Citation
 Mederski, WW; Osswald, M; Dorsch, D; Anzali, S; Christadler, M; Schmitges, CJ; Wilm, C Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Bioorg Med Chem Lett 8:17-22 (1999) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50069564
Synonyms:
5-Dimethylamino-naphthalene-1-sulfonic acid benzo[1,3]dioxol-5-ylamide | CHEMBL304761
Type:
Small organic molecule
Emp. Form.:
C19H18N2O4S
Mol. Mass.:
370.422
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1ccc2OCOc2c1
Structure:
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