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Target
Endothelin receptor type B
Ligand
BDBM50069572
Substrate
n/a
Meas. Tech.
ChEBML_63869
IC50
300±n/a nM
Citation
 Mederski, WW; Osswald, M; Dorsch, D; Anzali, S; Christadler, M; Schmitges, CJ; Wilm, C Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Bioorg Med Chem Lett 8:17-22 (1999) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50069572
Synonyms:
1-Benzo[1,2,5]thiadiazol-5-ylmethyl-4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-benzo[4,5]furo[3,2-b]pyridine-3-carboxylic acid | CHEMBL67971
Type:
Small organic molecule
Emp. Form.:
C26H17N3O5S
Mol. Mass.:
483.495
SMILES:
COc1ccc(cc1)-c1c(C(O)=O)c(=O)n(Cc2ccc3nsnc3c2)c2c3ccccc3oc12
Structure:
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