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Target
Guanine nucleotide-binding protein G(q) subunit alpha/subunit alpha-11
Ligand
BDBM50468902
Substrate
n/a
Meas. Tech.
ChEMBL_1856733 (CHEMBL4357462)
IC50
100±n/a nM
Citation
 Li, J; Ge, Y; Huang, JX; Strømgaard, K; Zhang, X; Xiong, XF Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery. J Med Chem 63:5013-5030 (2020) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(q) subunit alpha/subunit alpha-11
Synonyms:
GNAQ/GNA11
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1856733
Components:
This complex has 2 components.
Component 1
Name:
Guanine nucleotide-binding protein G(q) subunit alpha
Synonyms:
GAQ | GNAQ | GNAQ_HUMAN | Guanine nucleotide-binding protein G(q) subunit alpha | Guanine nucleotide-binding protein alpha-q
Type:
PROTEIN
Mol. Mass.:
42136.56
Organism:
Homo sapiens
Description:
ChEMBL_119337
Residue:
359
Sequence:
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
  
Component 2
Name:
Guanine nucleotide-binding protein subunit alpha-11
Synonyms:
G alpha-11 | G-protein subunit alpha-11 | GA11 | GNA11 | GNA11_HUMAN | Guanine nucleotide-binding protein G(y) subunit alpha | Guanine nucleotide-binding protein subunit alpha-11
Type:
PROTEIN
Mol. Mass.:
42118.31
Organism:
Homo sapiens
Description:
ChEMBL_117985
Residue:
359
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
  
Inhibitor
Name:
BDBM50468902
Synonyms:
CHEMBL4288881
Type:
Small organic molecule
Emp. Form.:
C46H69N7O15
Mol. Mass.:
960.078
SMILES:
CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: