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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50065058
Substrate
n/a
Meas. Tech.
ChEBML_28194
IC50
200±n/a nM
Citation
 Tanaka, A; Terasawa, T; Hagihara, H; Kinoshita, T; Sakuma, Y; Ishibe, N; Sawada, M; Takasugi, H; Tanaka, H Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring. Bioorg Med Chem Lett 8:81-6 (1999) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50065058
Synonyms:
1-(4-Methoxy-benzyl)-3-(6-methyl-2,4-bis-methylsulfanyl-pyridin-3-yl)-1-[3-(2H-pyrazol-3-yl)-benzyl]-urea | CHEMBL81707
Type:
Small organic molecule
Emp. Form.:
C27H29N5O2S2
Mol. Mass.:
519.681
SMILES:
COc1ccc(CN(Cc2cccc(c2)-c2cc[nH]n2)C(=O)Nc2c(SC)cc(C)nc2SC)cc1
Structure:
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