Reaction Details Report a problem with these data
Target
Kynureninase
Ligand
BDBM50069730
Substrate
n/a
Meas. Tech.
ChEBML_91722
Ki
70.0±n/a nM
Citation
 Drysdale, MJ; Reinhard, JF S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase. Bioorg Med Chem Lett 8:133-8 (1999) [PubMed]  Article 
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50069730
Synonyms:
2-Amino-3-(2-amino-benzenesulfonyl)-propionic acid | CHEMBL280572
Type:
Small organic molecule
Emp. Form.:
C9H12N2O4S
Mol. Mass.:
244.268
SMILES:
NC(CS(=O)(=O)c1ccccc1N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: