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Target
Nociceptin receptor
Ligand
BDBM50514555
Substrate
n/a
Meas. Tech.
ChEMBL_1857507 (CHEMBL4358236)
Ki
24±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514555
Synonyms:
CHEMBL4467156
Type:
Small organic molecule
Emp. Form.:
C25H38N4S
Mol. Mass.:
426.661
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CCNC(N)=S)c2ccccc12 |r,wD:6.9,3.2,(77.5,-21.25,;76.69,-19.93,;77.42,-18.58,;75.15,-19.98,;74.34,-18.67,;72.79,-18.71,;72.06,-20.07,;72.88,-21.38,;74.41,-21.34,;70.53,-20.13,;69.8,-21.48,;68.27,-21.53,;67.45,-20.23,;68.17,-18.86,;69.71,-18.81,;65.91,-20.28,;64.97,-19.06,;63.52,-19.59,;62.24,-18.73,;60.87,-19.41,;59.59,-18.55,;58.21,-19.23,;56.94,-18.37,;58.11,-20.76,;63.58,-21.13,;62.47,-22.2,;62.84,-23.69,;64.33,-24.11,;65.43,-23.04,;65.06,-21.56,)|
Structure:
Search PDB for entries with ligand similarity: