Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50514538
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
504±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514538
Synonyms:
CHEMBL4457077
Type:
Small organic molecule
Emp. Form.:
C25H39N3
Mol. Mass.:
381.5973
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CN(C)C)c2ccccc12 |r,wD:6.9,3.2,(22.93,-34.28,;22.12,-32.96,;22.85,-31.6,;20.58,-33,;19.77,-31.7,;18.22,-31.74,;17.5,-33.09,;18.31,-34.41,;19.85,-34.36,;15.96,-33.15,;15.23,-34.51,;13.7,-34.56,;12.88,-33.25,;13.6,-31.89,;15.15,-31.84,;11.35,-33.31,;10.4,-32.09,;8.95,-32.62,;7.68,-31.76,;7.78,-30.23,;6.51,-29.38,;9.16,-29.56,;9.01,-34.16,;7.91,-35.23,;8.28,-36.72,;9.76,-37.13,;10.86,-36.06,;10.49,-34.59,)|
Structure:
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