Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9
Ligand
BDBM50183449
Substrate
n/a
Meas. Tech.
ChEMBL_1858079 (CHEMBL4358808)
Kd
47±n/a nM
Citation
 Karim, RM; Chan, A; Zhu, JY; Schönbrunn, E Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J Med Chem 63:3227-3237 (2020) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 9
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 | Rhabdomyosarcoma antigen MU-RMS-40.8
Type:
PROTEIN
Mol. Mass.:
66994.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108000
Residue:
597
Sequence:
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
  
Inhibitor
Name:
BDBM50183449
Synonyms:
CHEMBL3823101 | US11773085, Compound B23
Type:
Small organic molecule
Emp. Form.:
C20H23N3O3
Mol. Mass.:
353.4149
SMILES:
COc1cc(c(OC)cc1CN(C)C)-c1cn(C)c(=O)c2cnccc12
Structure:
Search PDB for entries with ligand similarity: