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Target
Potassium channel subfamily K member 4
Ligand
BDBM50514764
Substrate
n/a
Meas. Tech.
ChEMBL_1858319 (CHEMBL4359048)
EC50
15290±n/a nM
Citation
 Qiu, Y; Huang, L; Fu, J; Han, C; Fang, J; Liao, P; Chen, Z; Mo, Y; Sun, P; Liao, D; Yang, L; Wang, J; Zhang, Q; Liu, J; Liu, F; Liu, T; Huang, W; Yang, H; Jiang, R TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem 63:3665-3677 (2020) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 4
Synonyms:
KCNK4 | KCNK4_HUMAN | Potassium channel subfamily K member 4 | TRAAK
Type:
PROTEIN
Mol. Mass.:
42711.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116447
Residue:
393
Sequence:
MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV
  
Inhibitor
Name:
BDBM50514764
Synonyms:
CHEMBL4552751
Type:
Small organic molecule
Emp. Form.:
C21H20N2O3S
Mol. Mass.:
380.46
SMILES:
Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](C2)C(O)=O)cc1 |r|
Structure:
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