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Target
Histamine H3 receptor
Ligand
BDBM50070217
Substrate
n/a
Meas. Tech.
ChEBML_86750
Ki
0.500000±n/a nM
Citation
 Ali, SM; Tedford, CE; Gregory, R; Yates, SL; Phillips, JG New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett 8:1133-8 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50070217
Synonyms:
3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-N-[2-(1H-imidazol-4-yl)-ethyl]-propionamide | CHEMBL15075 | VERONGAMINE
Type:
Small organic molecule
Emp. Form.:
C15H17BrN4O3
Mol. Mass.:
381.224
SMILES:
COc1ccc(CC(N=O)C(=O)NCCc2cnc[nH]2)cc1Br
Structure:
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