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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50167952
Substrate
n/a
Meas. Tech.
ChEMBL_1859656 (CHEMBL4360512)
EC50
519000±n/a nM
Citation
 Zhang, Z; Chen, H; Chen, Z; Ding, P; Ju, Y; Gu, Q; Xu, J; Zhou, H Identify liver X receptor ? modulator building blocks by developing a fluorescence polarization-based competition assay. Eur J Med Chem 178:458-467 (2019) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50167952
Synonyms:
3-chlorophenol | CHEMBL41172
Type:
Small organic molecule
Emp. Form.:
C6H5ClO
Mol. Mass.:
128.556
SMILES:
Oc1cccc(Cl)c1
Structure:
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