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Target
Sepiapterin reductase
Ligand
BDBM50515157
Substrate
n/a
Meas. Tech.
ChEMBL_1860096 (CHEMBL4360952)
IC50
680±n/a nM
Citation
 Alen, J; Schade, M; Wagener, M; Christian, F; Nordhoff, S; Merla, B; Dunkern, TR; Bahrenberg, G; Ratcliffe, P Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J Med Chem 62:6391-6397 (2019) [PubMed]  Article 
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM50515157
Synonyms:
CHEMBL4460459
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2NO2
Mol. Mass.:
322.186
SMILES:
Oc1cc(Cl)cc(Cl)c1C(=O)N1CCCc2ccccc12
Structure:
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