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Target
Lymphocyte antigen 96
Ligand
BDBM50515277
Substrate
n/a
Meas. Tech.
ChEMBL_1860752 (CHEMBL4361608)
Kd
2.4±n/a nM
Citation
 Achek, A; Shah, M; Seo, JY; Kwon, HK; Gui, X; Shin, HJ; Cho, EY; Lee, BS; Kim, DJ; Lee, SH; Yoo, TH; Kim, MS; Choi, S Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model. J Med Chem 62:6495-6511 (2019) [PubMed]  Article 
Target
Name:
Lymphocyte antigen 96
Synonyms:
ESOP-1 | ESOP1 | ESOP1 | LY96 | LY96_HUMAN | Ly-96 | Lymphocyte antigen 96 | MD2 | Protein MD-2 | TLR4-MD2
Type:
PROTEIN
Mol. Mass.:
18551.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107939
Residue:
160
Sequence:
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
  
Inhibitor
Name:
BDBM50515277
Synonyms:
CHEMBL4436411
Type:
Small organic molecule
Emp. Form.:
C74H105N15O15
Mol. Mass.:
1444.717
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CC(C)C)C(C)C |r|
Structure:
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