Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50070408
Substrate
n/a
Meas. Tech.
ChEBML_923
Ki
4±n/a nM
Citation
 Perez, M; Jorand-Lebrun, C; Pauwels, PJ; Pallard, I; Halazy, S Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes. Bioorg Med Chem Lett 8:1407-12 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50070408
Synonyms:
2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-yloxy]-1-(4-{2-[8-(4-methyl-piperazin-1-yl)-naphthalen-2-yloxy]-acetyl}-piperazin-1-yl)-ethanone | CHEMBL285402
Type:
Small organic molecule
Emp. Form.:
C38H46N6O4
Mol. Mass.:
650.8096
SMILES:
CN1CCN(CC1)c1cccc2ccc(OCC(=O)N3CCN(CC3)C(=O)COc3ccc4cccc(N5CCN(C)CC5)c4c3)cc12
Structure:
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