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Target
Estradiol 17-beta-dehydrogenase 1
Ligand
BDBM50515435
Substrate
n/a
Meas. Tech.
ChEMBL_1861112 (CHEMBL4361968)
IC50
388±n/a nM
Citation
 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem 62:7289-7301 (2019) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 1
Synonyms:
17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | DHB1_RAT | Edh17b1 | Estradiol 17-beta-dehydrogenase 1 | Hsd17b1
Type:
PROTEIN
Mol. Mass.:
36963.81
Organism:
Rattus norvegicus
Description:
ChEMBL_104363
Residue:
344
Sequence:
MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSLEILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVSGDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI
  
Inhibitor
Name:
BDBM50515435
Synonyms:
CHEMBL4513439
Type:
Small organic molecule
Emp. Form.:
C23H11F6NO4S2
Mol. Mass.:
543.458
SMILES:
Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(F)cc3)c(F)cc2F)c1F
Structure:
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