Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM81395
Substrate
n/a
Meas. Tech.
ChEMBL_1861503 (CHEMBL4362359)
IC50
2.7±n/a nM
Citation
 Travelli, C; Aprile, S; Mattoteia, D; Colombo, G; Clemente, N; Scanziani, E; Terrazzino, S; Alisi, MA; Polenzani, L; Grosa, G; Genazzani, AA; Tron, GC; Galli, U Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1
Type:
PROTEIN
Mol. Mass.:
55450.71
Organism:
Mus musculus
Description:
ChEMBL_108315
Residue:
491
Sequence:
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIEQDVAPH
  
Inhibitor
Name:
BDBM81395
Synonyms:
APO-866
Type:
Small organic molecule
Emp. Form.:
C24H29N3O2
Mol. Mass.:
391.506
SMILES:
O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1
Structure:
Search PDB for entries with ligand similarity: