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Target
Prothrombin
Ligand
BDBM50070781
Substrate
n/a
Meas. Tech.
ChEBML_208332
Ki
91±n/a nM
Citation
 Lee, K; Hwang, SY; Yun, M; Kim, DS Potent and efficacious thienylamidine-incorporated thrombin inhibitors. Bioorg Med Chem Lett 8:1683-6 (1999) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50070781
Synonyms:
1N-cyclopentyl-1N-methyl-3-[5-amino(aminoimino)methyl-2-thienyl]-2-(2-naphthylsulfonamido)-(2S)-propanamide | CHEMBL47908
Type:
Small organic molecule
Emp. Form.:
C24H29N5O3S2
Mol. Mass.:
499.649
SMILES:
CN(C1CCCC1)C(=O)[C@H](Cc1ccc(s1)C(N)=NN)NS(=O)(=O)c1ccc2ccccc2c1 |w:18.20|
Structure:
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