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Target
Substance-K receptor
Ligand
BDBM50071113
Substrate
n/a
Meas. Tech.
ChEBML_142729
Ki
40±n/a nM
Citation
 Jacobs, RT; Shenvi, AB; Mauger, RC; Ulatowski, TG; Aharony, D; Buckner, CK 4-Alkylpiperidines related to SR-48968: potent antagonists of the neurokinin-2 (NK2) receptor. Bioorg Med Chem Lett 8:1935-40 (1999) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50071113
Synonyms:
Acetic acid 2-{1-[4-(benzoyl-methyl-amino)-3-(3,4-dichloro-phenyl)-butyl]-piperidin-4-yl}-ethyl ester | CHEMBL57589
Type:
Small organic molecule
Emp. Form.:
C27H34Cl2N2O3
Mol. Mass.:
505.476
SMILES:
CN(CC(CCN1CCC(CCOC(C)=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1
Structure:
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