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Target
Thromboxane A2 receptor
Ligand
BDBM50010960
Substrate
n/a
Meas. Tech.
ChEBML_207647
Kd
8200±n/a nM
Citation
 Takeuchi, K; Kohn, TJ; Mais, DE; True, TA; Wyss, VL; Jakubowski, JA Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives. Bioorg Med Chem Lett 8:1943-8 (1999) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50010960
Synonyms:
(E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid(CV-4151) | CHEMBL26820 | CV-4151
Type:
Small organic molecule
Emp. Form.:
C18H19NO2
Mol. Mass.:
281.349
SMILES:
OC(=O)CCCC\C=C(/c1ccccc1)c1cccnc1
Structure:
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