Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50516230
Substrate
n/a
Meas. Tech.
ChEMBL_1863867 (CHEMBL4364842)
IC50
37090±n/a nM
Citation
 Zhan, W; Visone, J; Ouellette, T; Harris, JC; Wang, R; Zhang, H; Singh, PK; Ginn, J; Sukenick, G; Wong, TT; Okoro, JI; Scales, RM; Tumwebaze, PK; Rosenthal, PJ; Kafsack, BFC; Cooper, RA; Meinke, PT; Kirkman, LA; Lin, G Improvement of Asparagine Ethylenediamines as Anti-malarial  J Med Chem 62:6137-6145 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50516230
Synonyms:
CHEMBL4532885
Type:
Small organic molecule
Emp. Form.:
C25H31F3N4O5S
Mol. Mass.:
556.598
SMILES:
Cc1ccc(cc1)S(=O)(=O)N[C@@H](CC(=O)NC(C)(C)C)C(=O)NCCNC(=O)c1cccc(c1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: