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Target
Stromelysin-1
Ligand
BDBM50071244
Substrate
n/a
Meas. Tech.
ChEBML_101941
IC50
104±n/a nM
Citation
 Natchus, MG; Cheng, M; Wahl, CT; Pikul, S; Almstead, NG; Bradley, RS; Taiwo, YO; Mieling, GE; Dunaway, CM; Snider, CE; McIver, JM; Barnett, BL; McPhail, SJ; Anastasio, MB; De, B Design and synthesis of conformationally-constrained MMP inhibitors. Bioorg Med Chem Lett 8:2077-80 (1999) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50071244
Synonyms:
(2R,3R)-N*1*-Hydroxy-2-(3-hydroxy-propyl)-3-isobutyl-N*4*-[(S)-1-(2-methoxy-ethyl)-2-oxo-azepan-3-yl]-succinamide | CHEMBL66589
Type:
Small organic molecule
Emp. Form.:
C20H37N3O6
Mol. Mass.:
415.5243
SMILES:
COCCN1CCCC[C@H](NC(=O)[C@H](CC(C)C)[C@@H](CCCO)C(=O)NO)C1=O
Structure:
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