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Target
Interstitial collagenase
Ligand
BDBM50071250
Substrate
n/a
Meas. Tech.
ChEBML_101901
IC50
11±n/a nM
Citation
 Natchus, MG; Cheng, M; Wahl, CT; Pikul, S; Almstead, NG; Bradley, RS; Taiwo, YO; Mieling, GE; Dunaway, CM; Snider, CE; McIver, JM; Barnett, BL; McPhail, SJ; Anastasio, MB; De, B Design and synthesis of conformationally-constrained MMP inhibitors. Bioorg Med Chem Lett 8:2077-80 (1999) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50071250
Synonyms:
CHEMBL292545 | [(S)-3-((R)-2-Hydroxycarbamoylmethyl-decanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C21H37N3O6
Mol. Mass.:
427.535
SMILES:
CCCCCCCC[C@H](CC(=O)NO)C(=O)N[C@H]1CCCCN(CC(=O)OC)C1=O
Structure:
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