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Target
Peptide deformylase
Ligand
BDBM50291695
Substrate
n/a
Meas. Tech.
ChEBML_154319
Ki
37000±n/a nM
Citation
 Hu, YJ; Rajagopalan, PT; Pei, D H-phosphonate derivatives as novel peptide deformylase inhibitors. Bioorg Med Chem Lett 8:2479-82 (1999) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_ECOLI | PDF | Peptide Deformylase | Polypeptide deformylase | def | fms
Type:
Enzyme
Mol. Mass.:
19323.16
Organism:
Escherichia coli (strain K12)
Description:
The pdf gene from E. coli K12 was cloned and protein was expressed and purified from E. coli BL21(DE3).
Residue:
169
Sequence:
MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
  
Inhibitor
Name:
BDBM50291695
Synonyms:
CHEMBL84822 | H-PHOSPHONATE DERIVATIVE
Type:
Small organic molecule
Emp. Form.:
C18H28N3O7P
Mol. Mass.:
429.4046
SMILES:
CCCC[C@H](OP(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
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