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Target
Interleukin-5 receptor subunit alpha
Ligand
BDBM50354850
Substrate
n/a
Meas. Tech.
ChEMBL_1867280 (CHEMBL4368255)
IC50
26200±n/a nM
Citation
 Boggu, PR; Kim, Y; Jung, SH Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Interleukin-5 receptor subunit alpha
Synonyms:
CD_antigen=CD125 | IL-5 receptor subunit alpha | IL-5R subunit alpha | IL-5R-alpha | IL-5RA | IL5RA_MOUSE | Il5r | Il5ra | Interleukin-5 receptor subunit alpha
Type:
PROTEIN
Mol. Mass.:
46998.03
Organism:
Mus musculus
Description:
ChEMBL_118948
Residue:
415
Sequence:
MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF
  
Inhibitor
Name:
BDBM50354850
Synonyms:
BUDESONIDE | US10869929, Compound Budesonide | US11554172, Compound Budesonide | US11760775, Compound Budesonide
Type:
Small organic molecule
Emp. Form.:
C25H34O6
Mol. Mass.:
430.5339
SMILES:
CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO |r,c:15,t:11|
Structure:
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