Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50154375
Substrate
n/a
Meas. Tech.
ChEMBL_1868854 (CHEMBL4369920)
Ki
7410±n/a nM
Citation
 Tosh, DK; Rao, H; Bitant, A; Salmaso, V; Mannes, P; Lieberman, DI; Vaughan, KL; Mattison, JA; Rothwell, AC; Auchampach, JA; Ciancetta, A; Liu, N; Cui, Z; Gao, ZG; Reitman, ML; Gavrilova, O; Jacobson, KA Design and in Vivo Characterization of A J Med Chem 62:1502-1522 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50154375
Synonyms:
Adenosine receptor agonist, 16 | Ribavirin | Tribavirin | cid_37542 | med.21724, Compound 180
Type:
Small organic molecule
Emp. Form.:
C8H12N4O5
Mol. Mass.:
244.2047
SMILES:
NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
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