Reaction Details Report a problem with these data
Target
Urotensin-2 receptor
Ligand
BDBM50517320
Substrate
n/a
Meas. Tech.
ChEMBL_1868958 (CHEMBL4370024)
Ki
1.7±n/a nM
Citation
 Merlino, F; Billard, É; Yousif, AM; Di Maro, S; Brancaccio, D; Abate, L; Carotenuto, A; Bellavita, R; d'Emmanuele di Villa Bianca, R; Santicioli, P; Marinelli, L; Novellino, E; Hébert, TE; Lubell, WD; Chatenet, D; Grieco, P Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. J Med Chem 62:1455-1467 (2019) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
  
Inhibitor
Name:
BDBM50517320
Synonyms:
CHEMBL4568153
Type:
Small organic molecule
Emp. Form.:
C51H66N10O12S2
Mol. Mass.:
1075.26
SMILES:
CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: