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Target
Histamine H3 receptor
Ligand
BDBM50517521
Substrate
n/a
Meas. Tech.
ChEMBL_1869141 (CHEMBL4370207)
Ki
2.4±n/a nM
Citation
 Nirogi, R; Shinde, A; Mohammed, AR; Badange, RK; Reballi, V; Bandyala, TR; Saraf, SK; Bojja, K; Manchineella, S; Achanta, PK; Kandukuri, KK; Subramanian, R; Benade, V; Palacharla, RC; Jayarajan, P; Pandey, S; Jasti, V Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H J Med Chem 62:1203-1217 (2019) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50517521
Synonyms:
CHEMBL4574463
Type:
Small organic molecule
Emp. Form.:
C23H35N3O2
Mol. Mass.:
385.5429
SMILES:
O=C(NCCN1CCCC1)c1ccc(OC2CCN(CC2)C2CCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: