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Target
Proteasome subunit beta type-10
Ligand
BDBM50517597
Substrate
n/a
Meas. Tech.
ChEMBL_1869378 (CHEMBL4370444)
IC50
360±n/a nM
Citation
 Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, Y; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem 62:1626-1642 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50517597
Synonyms:
CHEMBL4589564
Type:
Small organic molecule
Emp. Form.:
C33H49N5O6S2
Mol. Mass.:
675.902
SMILES:
COC1CCC(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c2cnc(C)s2)C(=O)N[C@@H](Cc2ccc(CN)cc2)\C=C\S(C)(=O)=O)CC1 |r,wU:7.6,wD:28.29,11.11,(51.98,-17.05,;50.65,-16.28,;49.31,-17.04,;49.3,-18.58,;47.97,-19.35,;46.64,-18.57,;45.31,-19.34,;45.31,-20.88,;43.98,-21.65,;42.64,-20.88,;42.64,-19.34,;41.31,-21.65,;41.31,-23.19,;42.64,-23.95,;43.96,-23.17,;42.65,-25.48,;39.97,-20.88,;38.64,-21.65,;38.64,-23.19,;37.31,-20.88,;35.91,-21.49,;34.89,-20.35,;35.66,-19.02,;35.03,-17.62,;37.16,-19.35,;46.64,-21.65,;46.64,-23.19,;47.98,-20.88,;49.31,-21.65,;49.31,-23.19,;50.64,-23.96,;50.64,-25.5,;51.97,-26.27,;53.3,-25.5,;54.64,-26.27,;55.97,-25.49,;53.3,-23.95,;51.97,-23.19,;50.64,-20.88,;51.98,-21.65,;53.31,-20.87,;54.64,-21.65,;52.53,-19.53,;54.08,-19.53,;46.64,-17.03,;47.98,-16.27,)|
Structure:
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