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Target
Tubulin alpha-8 chain
Ligand
BDBM50517653
Substrate
n/a
Meas. Tech.
ChEMBL_1869428 (CHEMBL4370494)
IC50
26±n/a nM
Citation
 Coulup, SK; Huang, DS; Wong, HL; Georg, GI Identification of the Metabolic Profile of the ?-Tubulin-Binding Natural Product (-)-Pironetin. J Med Chem 62:1684-1689 (2019) [PubMed]  Article 
Target
Name:
Tubulin alpha-8 chain
Synonyms:
Alpha-tubulin 8 | TBA8_HUMAN | TUBA8 | TUBAL2 | Tubulin alpha chain-like 2 | Tubulin alpha-8 chain
Type:
PROTEIN
Mol. Mass.:
50075.35
Organism:
Homo sapiens
Description:
ChEMBL_116897
Residue:
449
Sequence:
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
  
Inhibitor
Name:
BDBM50517653
Synonyms:
Pironetin
Type:
Small organic molecule
Emp. Form.:
C19H32O4
Mol. Mass.:
324.455
SMILES:
CC[C@@H]1C=CC(=O)O[C@@H]1C[C@@H](O)[C@H](C)[C@H](OC)[C@@H](C)C\C=C\C |r,c:3|
Structure:
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