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Target
Serine protease 1
Ligand
BDBM50072293
Substrate
n/a
Meas. Tech.
ChEBML_212695
IC50
40±n/a nM
Citation
 Finch, H; Pegg, NA; McLaren, J; Lowdon, A; Bolton, R; Coote, SJ; Dyer, U; Montana, JG; Owen, MR; Dowle, M; Buckley, D; Ross, BC; Campbell, C; Dix, C; Mooney, C; Man-Tang, C; Patel, C 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor. Bioorg Med Chem Lett 8:2955-60 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50072293
Synonyms:
5-((3R,3aR,6aS)-2-Oxo-hexahydro-cyclopenta[b]furan-3-yl)-pentanamidine; compound with acetic acid | CHEMBL323543 | CHEMBL337572
Type:
Small organic molecule
Emp. Form.:
C12H20N2O2
Mol. Mass.:
224.2994
SMILES:
NC(=N)CCCC[C@@H]1[C@H]2CCC[C@@H]2OC1=O
Structure:
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