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Target
Cathepsin D
Ligand
BDBM50072544
Substrate
n/a
Meas. Tech.
ChEBML_45174
Ki
5300±n/a nM
Citation
 Carroll, CD; Johnson, TO; Tao, S; Lauri, G; Orlowski, M; Gluzman, IY; Goldberg, DE; Dolle, RE Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg Med Chem Lett 8:3203-6 (1999) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50072544
Synonyms:
(3S,4S)-3-Hydroxy-4-{2-[1-(4-isopropoxy-benzoyl)-4-(3,4,5-trimethoxy-benzyl)-piperazin-2-yl]-acetylamino}-5-phenyl-pentanoic acid butylamide | CHEMBL107770
Type:
Small organic molecule
Emp. Form.:
C41H56N4O8
Mol. Mass.:
732.9053
SMILES:
CCCCNC(=O)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)CC1CN(Cc2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1ccc(OC(C)C)cc1
Structure:
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