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Target
Kallikrein-7
Ligand
BDBM50518303
Substrate
n/a
Meas. Tech.
ChEMBL_1871083 (CHEMBL4372250)
IC50
>30000±n/a nM
Citation
 Murafuji, H; Muto, T; Goto, M; Imajo, S; Sugawara, H; Oyama, Y; Minamitsuji, Y; Miyazaki, S; Murai, K; Fujioka, H Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors. Bioorg Med Chem Lett 29:334-338 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM50518303
Synonyms:
CHEMBL4438651
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O2S
Mol. Mass.:
387.883
SMILES:
CN1CC(N=C1C)c1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)cc1 |c:4|
Structure:
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