Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50518420
Substrate
n/a
Meas. Tech.
ChEMBL_1871305 (CHEMBL4372472)
EC50
56±n/a nM
Citation
 Hall, A; Provins, L; Valade, A Novel Strategies To Activate the Dopamine D J Med Chem 62:128-140 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50518420
Synonyms:
CHEMBL4555682
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2NO
Mol. Mass.:
422.346
SMILES:
Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc32)c1Cl |TLB:25:26:10.12:19.14,11:10:19.14:26.21,15:14:10.12:26.21,18:19:10.12:26.21,THB:8:10:19.14:26.21,22:21:10.12:19.14,(38.46,-24.69,;37.07,-23.9,;37.08,-22.3,;35.69,-21.5,;34.31,-22.3,;32.93,-21.5,;34.32,-23.89,;32.93,-24.68,;32.93,-26.28,;34.31,-27.08,;30.28,-27.49,;29.13,-26.35,;31.13,-26.37,;31.13,-28.06,;29.51,-28.77,;28.85,-27.45,;27.38,-27.36,;26.57,-28.6,;27.24,-29.91,;28.7,-29.99,;30.28,-29.48,;31.59,-30.09,;32.35,-31.41,;33.89,-31.41,;34.65,-30.07,;33.87,-28.75,;32.35,-28.76,;35.69,-24.69,;35.69,-26.28,)|
Structure:
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