Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50518419
Substrate
n/a
Meas. Tech.
ChEMBL_1871305 (CHEMBL4372472)
EC50
250±n/a nM
Citation
 Hall, A; Provins, L; Valade, A Novel Strategies To Activate the Dopamine D J Med Chem 62:128-140 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50518419
Synonyms:
CHEMBL4519136
Type:
Small organic molecule
Emp. Form.:
C25H28BrClN2O2
Mol. Mass.:
503.859
SMILES:
[H][C@@]12C[C@@]1(CC[C@H](C2)N1CCN(Cc2cc(Cl)ccc2Br)CC1)c1ccc2OCOc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: