Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50518422
Substrate
n/a
Meas. Tech.
ChEMBL_1871305 (CHEMBL4372472)
EC50
22±n/a nM
Citation
 Hall, A; Provins, L; Valade, A Novel Strategies To Activate the Dopamine D J Med Chem 62:128-140 (2019) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50518422
Synonyms:
CHEMBL4448100
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2NO
Mol. Mass.:
422.346
SMILES:
Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc21 |TLB:27:28:11.13:20.15,12:11:20.15:28.22,16:15:11.13:28.22,19:20:11.13:28.22,THB:9:11:20.15:28.22,23:22:11.13:20.15|
Structure:
Search PDB for entries with ligand similarity: