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Target
Kappa-type opioid receptor
Ligand
BDBM50518462
Substrate
n/a
Meas. Tech.
ChEMBL_1871635 (CHEMBL4372802)
Ki
18±n/a nM
Citation
 Tangherlini, G; Kalinin, DV; Schepmann, D; Che, T; Mykicki, N; Ständer, S; Loser, K; Wünsch, B Development of Novel Quinoxaline-Based ?-Opioid Receptor Agonists for the Treatment of Neuroinflammation. J Med Chem 62:893-907 (2019) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50518462
Synonyms:
CHEMBL4483681
Type:
Small organic molecule
Emp. Form.:
C25H35Cl2N3O3
Mol. Mass.:
496.47
SMILES:
[H][C@]12CCC[C@H](N3CCCC3)[C@@]1([H])N(CCN2C(=O)OC(C)(C)C)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Structure:
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