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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50518473
Substrate
n/a
Meas. Tech.
ChEMBL_1871669 (CHEMBL4372836)
Ki
414±n/a nM
Citation
 Xu, Y; Sromek, AW; Neumeyer, JL Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT Bioorg Med Chem Lett 29:230-233 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50518473
Synonyms:
CHEMBL4580763
Type:
Small organic molecule
Emp. Form.:
C27H27ClFNO3
Mol. Mass.:
467.96
SMILES:
Cl.[H][C@]12Cc3cccc(OC(=O)c4ccc(F)cc4)c3-c3cc(OC)cc(CCN1CCC)c23 |r|
Structure:
Search PDB for entries with ligand similarity: