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Target
Thromboxane A2 receptor
Ligand
BDBM50072786
Substrate
n/a
Meas. Tech.
ChEMBL_210267 (CHEMBL809291)
Kd
113.3±n/a nM
Citation
 Takeuchi, K; Kohn, TJ; True, TA; Mais, DE; Wikel, JH; Utterback, BG; Wyss, VL; Jakubowski, JA Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds. J Med Chem 41:5362-74 (1999) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50072786
Synonyms:
(E)-7-{4-[4-(2-Cyclohexyloxy-ethylcarbamoyl)-oxazol-2-yl]-phenyl}-7-pyridin-3-yl-hept-6-enoic acid | CHEMBL150289
Type:
Small organic molecule
Emp. Form.:
C30H35N3O5
Mol. Mass.:
517.616
SMILES:
OC(=O)CCCC\C=C(/c1ccc(cc1)-c1nc(co1)C(=O)NCCOC1CCCCC1)c1cccnc1
Structure:
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